Programa de Pós Graduação em Bioinformática

Helder Takashi Imoto Nakaya

É pesquisador sênior do Hospital Israelita Albert Einstein e professor em regime parcial da Faculdade de Ciências Farmacêuticas da Universidade de São Paulo (USP). Co-fundador e chief scientific officer da startup nacional D2DNA e da startup dinamarquesa Synamics Therapeutics. Também é professor adjunto da Universidade Emory, em Atlanta, nos Estados Unidos, e foi vice-diretor da FCF-USP. Membro do Conselho Deliberativo da Sociedade Brasileira de Imunologia e da diretoria da Associação Brasileira de Bioinformática e Biologia Computacional. Foi membro afiliado da Academia Brasileira de Ciências (ABC), consultor da CEPI (Coalition for Epidemic Preparedness Innovations) e da IUIS (International Union of Immunological Societies) e membro do conselho consultivo científico do consórcio europeu da vacina do ebola e do Instituto Internacional de Análise de Sistemas Aplicados (IIASA). Website do laboratório de Biologia de Sistemas Computacional: www.csbiology.org (Texto informado pelo autor)

  • http://lattes.cnpq.br/5515247461567730 (11/06/2024)
  • Rótulo/Grupo:
  • Bolsa CNPq: Nível 1B
  • Período de análise:
  • Endereço: Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein. Rua Comendador Elias Jafet 755 Morumbi 05653000 - São Paulo, SP - Brasil Telefone: (11) 21511001 URL da Homepage: csbiology.org
  • Grande área: Ciências Biológicas
  • Área: Bioquímica
  • Citações: Google Acadêmico

Produção bibliográfica

Produção técnica

Produção artística

Orientações em andamento

Supervisões e orientações concluídas

Projetos de pesquisa

Prêmios e títulos

Participação em eventos

Organização de eventos

Lista de colaborações

Produção bibliográfica

Produção técnica

Produção artística

Orientações em andamento

Supervisões e orientações concluídas

Projetos de pesquisa

  • Total de projetos de pesquisa (18)
    1. 2020-Atual. Development of SARS-CoV-2 low-cost diagnostic platform based on reverse-transcription loop-mediated isothermal amplification (RT-LAMP).
      Descrição: To provide a solution for a rapid response of high laboratory diagnostic demand in virus outbreaks in PINA (RIIP).. Situação: Em andamento; Natureza: Pesquisa. Integrantes: Helder Takashi Imoto Nakaya - Integrante / edison Durigon - Coordenador / lucas blanes - Integrante. Financiador(es): Institut Pasteur - Auxílio financeiro.
      Membro: Helder Takashi Imoto Nakaya.
    2. 2020-Atual. Systems immunology approach for resolving the mechanisms of vaccine-induced classical swine fever protection
      Descrição: Classical Swine Fever (CSF) is a contagious, haemorrhagic and often fatal disease of Suidae, such as pigs and wild boar, caused by the classical swine fever virus (CSFV). CSFV is an enveloped, single stranded RNA virus that belongs to the Flaviviridae family (Moennig, 2000), distantly related for example to Zika and Yellow Fever virus. CSFV can be controlled by vaccination particularly using the C strain vaccine. The vaccine provides a rapid and complete protection of pigs against infection and also prevents viral transmission within 5 days of vaccination. The immunological signalling cascades behind the early protection afforded by C Strain are poorly understood, but precede the adaptive response, where IFN³+ CD8+ cells arrive before the detection of a virus neutralising antibody response. Interferon is a key component of how the innate immune system responds to challenge with CSFV. System Immunology approaches have been carried out in humans for example on the highly efficacious Yellow Fever vaccine. Deciphering the immune signalling pathways underpinning the effectiveness of the C strain vaccine can shape and optimise the next generation of marker and subunit vaccines well beyond CSFV as access to material including post-mortem tissues where required is not limited. Previous work has indicated a key role of the interferon system if stimulated prior to challenge. The team at UoS has already carried out studies further to the one mentioned above to characterise the action of CSFV C strain vaccine upon vaccination. In particular we have carried out one study sampling tonsils at various time points in the first 90 hours, comparing C-strain and a virulent challenge virus to baseline. Samples have been stored for subsequent analysis by deep sequencing, which will be carried out in 2019. For early 2020 another such study is planned into the design of which the team at USP will provide input. The project is specifically designed to foster the collaboration between Prof Nakaya's team at USP and Prof Steinbach's team in Surrey through collaborative visits in particular. The aim is to generate data in collaboration from which publications and further grant applications will be generated in the course of the project.. Situação: Em andamento; Natureza: Pesquisa. Integrantes: Helder Takashi Imoto Nakaya - Coordenador / Falko Steinbach - Integrante. Financiador(es): Fundação de Amparo à Pesquisa do Estado de São Paulo - Auxílio financeiro.
      Membro: Helder Takashi Imoto Nakaya.
    3. 2020-Atual. Validation of Plasmodium falciparum antigens targeted by human CD8+ T cells using T Cell Receptor-expressing reporter cells
      Descrição: In collaboration with Dr Helder Nakaya (Scientific Platform Pasteur USP, Brazil) an expert in systems vaccinology and single-­‐cell immunoprofiling25,26, we intend to use Cellular Indexing of Transcriptomes and Epitopes by Sequencing (CITE-­‐Seq)29 to single-­‐cell sequence CTLs using barcoded dextramers harboring the epitopes discovered by immunopeptidomics. This method will allow us to maximize the use of the small numbers of specific T cells from the humanized mice to retrieve the sequences of epitope-­‐specific variable regions of T cell receptors (TCRs). TCRs will be expressed on reporter cells which will become fluorescent after TCR activation by the complex peptide-­‐MHC class I molecule30. Thus, to validate Pf ATCs instead of focusing on the elimination of infected hepatocytes, which can depend on non-­‐specific factors, such as secreted cytokines in vitro, or yet on the high amounts of CTLs that will be determined by the immunization method/model in vivo, we propose to rely on the specific-­‐TCR activation of reporter cells by epitopes presented on the surface of Pf infected hepatocytes.. Situação: Em andamento; Natureza: Pesquisa. Integrantes: Helder Takashi Imoto Nakaya - Integrante / Rogerio Amino - Coordenador. Financiador(es): Institut Pasteur - Auxílio financeiro.
      Membro: Helder Takashi Imoto Nakaya.
    4. 2019-Atual. Integrated strategy for the study of infectious agents causing emerging and / or neglected diseases transmitted by vectors of global impact
      Descrição: This new Pasteur / USP partnership is particularly focused on vector-borne emergent and neglected diseases that may cause very complex immune responses and serious anomalies and / or disturbances in the nervous system, consequently impacting animal and public health. These partners will join their forces in a new Scientific Platform, in the recent "Innovation Center InovaUSP", in spaces strategically designed to implement a novel model for performing scientific research in proximity to the academy. The technological objective of this Platform is to strengthen the development of joint initiatives with a high degree of infrastructures and state-of-the-art equipment, sharing expertise, technologies and know-how, in view of joint and innovative discoveries of products and processes. This project is structured around complementary research programs of 3 groups of researchers from the two institutions that, in concert through this task force, intend to strengthen their scientific ties by answering questions of medical and veterinary interest in this unique strategic environment. The project aims to achieve the following main scientific objectives: (i) Generate luminous and fluorescent microorganisms to allow the real-time and detailed analysis of the interaction of these microorganisms with their hosts; (ii) To decipher immune, inflammatory and pathogenetic mechanisms triggered by these infectious agents, notably in the brain; (iii). Build a database from the integration of results generated by Omics, molecular biology and immunology and; (iv). Identify new targets for the development of preventive, diagnostic / prognostic and therapeutic methods.. Situação: Em andamento; Natureza: Pesquisa. Integrantes: Helder Takashi Imoto Nakaya - Coordenador / Patricia Cristina Baleeiro Beltrao Braga - Integrante / Paola Marcella Camargo Minoprio - Integrante / Edison Luiz Durigon - Integrante / Eduardo Massad - Integrante / Paolo Marinho de Andrade Zanotto - Integrante / Pedro Cesar Teixeira Silva - Integrante. Financiador(es): Fundação de Amparo à Pesquisa do Estado de São Paulo - Auxílio financeiro.
      Membro: Helder Takashi Imoto Nakaya.
    5. 2019-Atual. Integrative Biology Applied to Human Health
      Descrição: Data related to human health, from clinical and epidemiological information to medical images and omics data, are being generated and accumulated in an unprecedented amount in history. The analysis and integration of such information is critical to improve our understanding of the pathophysiology of diseases, their transmission, as well as their diagnosis and treatment. This project proposes innovative approaches for: analyzing large epidemiological databases; mapping hotspots of disease transmission; integrating transcriptome data with clinical and immunological data; and using machine learning for interpretation and analysis of microscopic images. State-of-the-art techniques or systems analyses and machine learning will be used and even developed for each approach, taking into account the foundations of integrative biology. We hope that the results of the project can clarify several problems related to human health, from the automatic analysis of microscopic slides to the molecular mechanisms of infectious and inflammatory diseases. Situação: Em andamento; Natureza: Pesquisa. Integrantes: Helder Takashi Imoto Nakaya - Coordenador / Mario Hiroyuki Hirata - Integrante / Luís Carlos de Souza Ferreira - Integrante / Luciano da Fontoura Costa - Integrante / Fernando Augusto Bozza - Integrante / Patricia Cristina Baleeiro Beltrao Braga - Integrante / Esper Georges Kallás - Integrante / Frederico Moraes Ferreira - Integrante / Paola Marcella Camargo Minoprio - Integrante / Ricardo Tostes Gazzinelli - Integrante / Sergio Schenkman - Integrante / Vanderson de Souza Sampaio - Integrante. Financiador(es): Fundação de Amparo à Pesquisa do Estado de São Paulo - Auxílio financeiro.
      Membro: Helder Takashi Imoto Nakaya.
    6. 2019-Atual. Network statistics: theory, methods, and applications
      Descrição: The importance of statistics in natural sciences is unquestionable. Statistics is essential to analyze data appropriately and to reach reliable conclusions. However, little is known about formal statistical methods on graphs and their theoretical properties even with an increasing number of reports on the analysis of real world networks (e.g. functional brain networks, protein-protein interaction networks, and social interaction networks). Networks are usually analyzed using computational algorithms based on graph theory, such as calculation of centrality measures (relative importance of vertices and edges) or identification of structural patterns (motifs). The main drawback of this approach is the fact that real world networks present intrinsic fluctuations (random noise) that are not taken into account by these "classical" algorithms. Therefore, methods with statistical perspective may aid and complement these analyses. The main goals of this proposal is the development of both theory and computational statistics methods and apply them to real world data, such as networks from molecular biology, neuroimaging, and cardiac data. The development of this project will be essential to obtain novel insights, solidify the cooperation among PIs, and improve the research quality of all involved groups. In the long term, we will consolidate the field of Network Statistics, form groups of highly qualified researchers, and ultimately build a Center for Network Statistics in Brazil. This center will develop novel theoretical frameworks, methodological tools and also apply the latter to solve health sciences problems.. Situação: Em andamento; Natureza: Pesquisa. Integrantes: Helder Takashi Imoto Nakaya - Integrante / André Fujita - Coordenador / Ronaldo Fumio Hashimoto - Integrante / João Ricardo Sato - Integrante / José Carlos Farias Alves Filho - Integrante / Thiago Mattar Cunha - Integrante / David Corrêa Martins Júnior - Integrante / Abner Cardoso Rodrigues Neto - Integrante / Alexandre Alarcon Steiner - Integrante / Alexandre Galvão Patriota - Integrante / Andrea Parolin Jackowski - Integrante / Carlos Alberto Moreira Filho - Integrante / Claudinei Eduardo Biazoli Junior - Integrante / Daniel Yasumasa Takahashi - Integrante / Elisa Harumi Kozasa - Integrante / Fabricio Martins Lopes - Integrante / Itamar de Souza Santos - Integrante / Joana Bisol Balardin - Integrante / João Paulo Papa - Integrante / MARI CLEIDE SOGAYAR - Integrante / Rodrigo Affonseca Bressan - Integrante / Silvia Yumi Bando Takahara - Integrante. Financiador(es): Fundação de Amparo à Pesquisa do Estado de São Paulo - Auxílio financeiro.
      Membro: Helder Takashi Imoto Nakaya.
      Descrição: The importance of statistics in natural sciences is unquestionable. Statistics is essential to analyze data appropriately and to reach reliable conclusions. However, little is known about formal statistical methods on graphs and their theoretical properties even with an increasing number of reports on the analysis of real world networks (e.g. functional brain networks, protein-protein interaction networks, and social interaction networks). Networks are usually analyzed using computational algorithms based on graph theory, such as calculation of centrality measures (relative importance of vertices and edges) or identification of structural patterns (motifs). The main drawback of this approach is the fact that real world networks present intrinsic fluctuations (random noise) that are not taken into account by these "classical" algorithms. Therefore, methods with statistical perspective may aid and complement these analyses. The main goals of this proposal is the development of both theory and computational statistics methods and apply them to real world data, such as networks from molecular biology, neuroimaging, and cardiac data. The development of this project will be essential to obtain novel insights, solidify the cooperation among PIs, and improve the research quality of all involved groups. In the long term, we will consolidate the field of Network Statistics, form groups of highly qualified researchers, and ultimately build a Center for Network Statistics in Brazil. This center will develop novel theoretical frameworks, methodological tools and also apply the latter to solve health sciences problems.. Situação: Em andamento; Natureza: Pesquisa. Integrantes: André Fujita - Coordenador / Joao Ricardo Sato - Integrante / Helder Nakaya - Integrante. Financiador(es): (FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo - Auxílio financeiro.
      Membro: André Fujita.
    7. 2019-Atual. Aplicação da imunologia de sistemas para a resolução dos mecanismos de proteção contra a Peste Suína Clássica induzida por vacina
      Descrição: A Peste Suína Clássica (PSC) é uma doença contagiosa, hemorrágica e muitas vezes fatal de Suidae, como porcos e javalis, causada pelo vírus da peste suína clássica (CSFV). O CSFV é um vírus de RNA de fita simples, envelopado, que pertence à família Flaviviridae (Moennig, 2000), relacionado, por exemplo, ao vírus da Zika e da Febre Amarela. O CSFV pode ser controlado por vacinação, particularmente utilizando a vacina da cepa C. A vacina fornece uma proteção rápida e completa dos porcos contra a infecção e também previne a transmissão viral dentro de 5 dias da vacinação.As cascatas de sinalização imunológica por trás da proteção precoce proporcionada pela cepa C são mal compreendidas, mas precedem a resposta adaptativa, em que as células CD8+ IFNg+ chegam antes da detecção de uma resposta de anticorpos neutralizadores de vírus. O interferon é um componente chave de como o sistema imune inato responde ao desafio com o CSFV. As abordagens de imunologia do sistema foram realizadas em humanos, por exemplo, na vacina altamente eficaz da Febre Amarela. Decifrar as vias de sinalização imune que sustentam a eficácia da vacina da cepa C pode moldar e otimizar a próxima geração de vacinas marcadoras e de subunidades bem além do CSFV, pois o acesso ao material, incluindo os tecidos post-mortem, quando necessário, não é limitado. Trabalhos anteriores indicaram um papel fundamental do sistema interferon se estimulado antes do desafio. A equipe da UoS já realizou estudos adicionais ao mencionado acima para caracterizar a ação da vacina contra a cepa C do CSFV após a vacinação. Em particular, realizamos um estudo amostrando amígdalas em vários momentos nas primeiras 90 horas, comparando a linhagem C e um vírus de desafio virulento à linha de base. As amostras foram armazenadas para posterior análise por sequenciamento profundo, que será realizado em 2019. Para o início de 2020, outro projeto desse tipo está planejado para o projeto, do qual a equipe da USP fornecerá dados.O projeto é especificamente projetado para promover a colaboração entre a equipe do Prof Nakaya na USP e a equipe do Prof Steinbach em Surrey, através de visitas colaborativas em particular. O objetivo é gerar dados em colaboração a partir dos quais as publicações e outras solicitações de subsídios serão geradas no decorrer do projeto.. Situação: Em andamento; Natureza: Pesquisa. Integrantes: Helder Takashi Imoto Nakaya - Coordenador / Falko Steinbach - Integrante. Financiador(es): Fundação de Amparo à Pesquisa do Estado de São Paulo - Auxílio financeiro.
      Membro: Helder Takashi Imoto Nakaya.
    8. 2017-2018. Zoetis LLC - Systems Biology Approaches to Understand Bovine Respiratory Disease
      Descrição: We will apply cutting-edge systems biology approaches to decipher cattle response to BRD. Through network analyses, our goal is to combine in depth cattle immune, transcriptomic and metabolomics profiling to identify key targets for disease intervention or therapeutics.. Situação: Concluído; Natureza: Pesquisa. Integrantes: Helder Takashi Imoto Nakaya - Coordenador.
      Membro: Helder Takashi Imoto Nakaya.
    9. 2017-Atual. Long noncoding RNA interplay with the host microbiome may determine mucosal influenza vaccine immunogenicity
      Descrição: To apply systems biology methods to integrate nasopharyngeal microbiome, mucosal and blood transcriptome, immunological and clinical data following intranasal live attenuated influenza vaccine in children, and to identify and investigate the putative role of long noncoding RNAs (lncRNAs) in vaccine-induced mucosal immunity.. Situação: Em andamento; Natureza: Pesquisa. Alunos envolvidos: Mestrado acadêmico: (2) Doutorado: (1) . Integrantes: Helder Takashi Imoto Nakaya - Coordenador / Thushan de Silva - Integrante / Beate Kampmann - Integrante. Financiador(es): Fundação de Amparo à Pesquisa do Estado de São Paulo - Cooperação.
      Membro: Helder Takashi Imoto Nakaya.
    10. 2017-Atual. Bill & Melinda Gates Foundation: "Mapping Hotspots for Mosquito-Human Malaria Transmission"
      Descrição: GRAND CHALLENGES EXPLORATIONS da Bill & Melinda Gates Foundation Helder Nakaya of the University of Sao Paulo in Brazil will identify hotspots of malaria transmission using the GPS data from mobile phones of infected individuals in order to find asymptomatic cases and help elimination efforts. Malaria is a major public health concern in many countries including Brazil. Eliminating the disease is difficult due in part to the existence of asymptomatic individuals who can still spread the disease but are difficult to detect. Relying on a patient remembering where they have been to identify asymptomatic individuals has not been adequate. Instead, they will test their online tool, which can extract the location history of an individual that has been recorded on their mobile phone, using patients with malaria in a reference hospital in Manaus, Brazil. The tool will be used to identify potential hotspots of transmission, which will be verified by taking blood samples from residents to identify those elusive asymptomatic patients. They will also develop an application for health care workers that displays the hotspots on a map.. Situação: Em andamento; Natureza: Pesquisa. Alunos envolvidos: Graduação: (3) / Mestrado acadêmico: (2) / Doutorado: (1) . Integrantes: Helder Takashi Imoto Nakaya - Coordenador / Daniel Bargieri - Integrante / Marcus Lacerda - Integrante. Financiador(es): Bill & Melinda Gates Foundation - Auxílio financeiro.
      Membro: Helder Takashi Imoto Nakaya.
    11. 2016-Atual. Systems analysis of adult and pediatric responses to the VSV-ZEBOV Ebola vaccine
      Descrição: The VSV-EBOPLUS collaborative research project is aimed to decipher the immune and molecular signatures of adult and pediatric responses elicited by the rVSVrG-ZEBOV-GP vaccine, the only Ebola vaccine with demonstrated 100% protective efficacy in humans. VSV-EBOPLUS will apply advanced cutting-edge technologies and systems vaccinology approaches to characterize the signatures of the responses to rVSVrG-ZEBOV-GP vaccination in clinical studies conducted in three different continents (Europe, Africa, US), in almost 1?000 adults, adolescents and children. VSV-EBOPLUS is a public-private consortium of 11 partners from 8 different countries involving experts from academic and research institutions, clinical sites (Switzerland, Gabon, USA) and the rVSVrG-ZEBOV-GP vaccine manufacturer. The project, of the duration of 5 years, has a total budget of more than ?15 million, and it is funded by the Innovative Medicines Initiative 2 (IMI 2) Joint Undertaking.. Situação: Em andamento; Natureza: Pesquisa. Integrantes: Helder Takashi Imoto Nakaya - Coordenador / Donata Medaglini - Integrante / Claire-Anne Siegrist - Integrante / Selidji Agnandji - Integrante / Michael Eichberg - Integrante / Ali Harandi - Integrante / Tom Ottenhoff - Integrante. Financiador(es): Innovative Medicines Initiative - Auxílio financeiro.
      Membro: Helder Takashi Imoto Nakaya.
    12. 2015-2017. Systems biology of typhoid fever: Unravelling regulation of human host-responses to infection with Salmonella Typhi and live oral vaccination
      Descrição: Systems biology of typhoid fever: Unravelling regulation of human host-responses to infection with Salmonella Typhi and live oral vaccination. Situação: Concluído; Natureza: Pesquisa. Alunos envolvidos: Mestrado acadêmico: (1) . Integrantes: Helder Takashi Imoto Nakaya - Coordenador / Andrew Pollard - Integrante. Financiador(es): Fundação de Amparo à Pesquisa do Estado de São Paulo - Cooperação.
      Membro: Helder Takashi Imoto Nakaya.
    13. 2014-2018. Improving treatment strategies for chronic alphaviral arthritic diseases
      Descrição: Chikungunya virus (CHIKV) and Ross River virus (RRV) cause (occasionally very large) outbreaks of polyarthritis/polyarthralgia, which is often debilitating, lasts from weeks to months (occasionally longer), and is generally poorly managed with current treatments. Aim: To use RNA-Seq analysis to characterise the inflammatory signatures and viral genomes associated with chronic arthritis.. Situação: Concluído; Natureza: Pesquisa. Integrantes: Helder Takashi Imoto Nakaya - Integrante / Andreas Suhrbier - Coordenador.
      Membro: Helder Takashi Imoto Nakaya.
    14. 2014-2016. Meta-análise transcricional de RNAs não codificadores longos de posições genômicas conservadas
      Descrição: It is estimated that thousands of long non-coding RNAs (lncRNAs) are transcribed in the genome of several organisms. Dr. Kouzarides? group at Cambridge University re-analyzed a vast amount of RNA-sequencing data, and identified ~600 lncRNAs that were ?positionally conserved? (pcRNAs) in human and mouse genomes. Among the genes associated with these pcRNAs, a striking enrichment was observed for loci related to embryonic and tissue development. They also demonstrated that pcRNA expression is highly tissue-specific and directly correlates with the associated coding genes, supporting the idea that pcRNAs are context-specific regulators of developmental genes. Our group at University of São Paulo is utilizing publicly available high-throughput data to investigate the expression of lncRNAs under hundreds of different perturbations and conditions, and studying the implication of lncRNAs in the regulation of candidate target genes. We compared the genomic regions of these ~600 pcRNAs with the genomic regions of probes from different microarray platforms and found that most of these pcRNAs are represented by one or more probes. Here we propose to analyse the expression patterns of these pcRNAs, and how their expression correlates with the expression of coding genes, in a large panel of human cancer cell lines, primary tumours and disease conditions. The functions of a number of selected pcRNAs will be validated by Dr. Kouzarides' group. By assessing the transcription of pcRNAs and their associated coding genes in thousands of microarray studies, we expect to identify the biological conditions that affect the most the expression of pcRNAs and to reveal interesting mechanisms of gene regulation.. Situação: Concluído; Natureza: Pesquisa. Integrantes: Helder Takashi Imoto Nakaya - Coordenador / Paulo Paiva Amaral - Integrante / Tony Kouzarides - Integrante. Financiador(es): Fundação de Amparo à Pesquisa do Estado de São Paulo - Auxílio financeiro.
      Membro: Helder Takashi Imoto Nakaya.
    15. 2014-2016. Biologia de Sistemas de Processos Inflamatórios
      Descrição: As redes gênicas que coordenam os diferentes processos inflamatórios são extremamente complexas e podem envolver centenas de genes. Entender precisamente quais componentes e as interações entre eles relevantes em uma determinada condição inflamatória pode fornecer importantes candidatos a alvos de fármacos, mais específicos e com menos efeitos adversos.. Situação: Concluído; Natureza: Pesquisa. Alunos envolvidos: Graduação: (1) / Especialização: (1) . Integrantes: Helder Takashi Imoto Nakaya - Coordenador / sandro rogerio de Almeida - Integrante / Dario Simões Zamboni - Integrante. Financiador(es): Conselho Nacional de Desenvolvimento Científico e Tecnológico - Auxílio financeiro.
      Membro: Helder Takashi Imoto Nakaya.
    16. 2014-Atual. Systems biological analyses of innate and adaptive responses to vaccination
      Descrição: The ability to predict vaccine immunity offers a solution to a major challenge in vaccinology: to prospectively determine vaccine efficacy. This ability is of considerable public health importance in identifying ?non-responders? in special populations in which a vaccine may induce suboptimal immunity. In addition, it would be great value in clinical trials of novel vaccines, to provide a rapid means to assess vaccine efficacy, without the need to identify the incidence of the target disease in vaccinated versus unvaccinated populations. In this context, this ?systems vaccinology? approach is beginning to be used to define signatures of vaccine efficacy in clinical trials. Importantly, this approach is yielding new insights about the fundamental mechanisms of immunity. Situação: Em andamento; Natureza: Pesquisa. Integrantes: Helder Takashi Imoto Nakaya - Integrante / Pulendran, Bali - Coordenador. Financiador(es): NIH - Auxílio financeiro.
      Membro: Helder Takashi Imoto Nakaya.
    17. 2013-2018. Biologia de Sistemas de Longos RNAs não-codificadores
      Descrição: Estima-se que milhares de longos RNAs não-codificadores (lncRNAs) sejam gerados à partir da transcrição do genoma de diversos organismos. No entanto, apenas uma fração muito pequena destes foi caracterizada funcionalmente. Um dos maiores motivos para isso está em nossa falta de conhecimento sobre os tecidos e condições biológicas nos quais esses lncRNAs são transcritos e como eles interagem com o DNA ou outros RNAs. A maioria dos estudos que utilizam técnicas de larga-escala como microarrays e sequenciamento de nova geração (RNA-seq) tem como objetivo principal monitorar a expressão dos genes codificadores de proteína. Porém, muitos destes dados, não explorados nas publicações originais, são provenientes de lncRNAs. Neste projeto, nós propomos utilizar os milhares de estudos de microarrays disponíveis em um banco de dados público para estudar a biologia de sistema dos lncRNAs frente a diferentes perturbações e suas possíveis implicações na regulação de genes alvos. Uma re-anotação que fizemos da plataforma da Affymetrix mais usada, na qual mais de 2.300 estudos foram publicados, revelou a existência de 10.248 sondas que medem a expressão de possíveis lncRNAs. Estudar o perfil de expressão de lncRNAs e como estes se correlacionam com os perfis de genes codificadores de proteína em tantos tecidos e condições irá revelar mecanismos de regulação interessantes. Estas análises irão envolver a identificação de módulos de co-expressão, a predição dos fatores de transcrição envolvidos e a associação de lncRNAs com doenças e infecções. Propomos também validar o papel regulatório de lncRNAs em alguns desses achados.. Situação: Concluído; Natureza: Pesquisa. Integrantes: Helder Takashi Imoto Nakaya - Coordenador / Marina Baquerizo Martinez - Integrante / Mario Hiroyuki Hirata - Integrante / Vinicius Ramos Henriques Maracaja Coutinho - Integrante. Financiador(es): Fundação de Amparo à Pesquisa do Estado de São Paulo - Auxílio financeiro.
      Membro: Helder Takashi Imoto Nakaya.
    18. 2013-Atual. CRID - Center for research in inflammatory diseases
      Descrição: Inflammatory diseases are a complex and heterogeneous group of diseases that affect more than 10% of the word population. The current options for the treatment of these diseases are still limited and in some cases, inefficient due to limited understanding of the mechanisms underlying these diseases. The development of translational research by a center that can generate scientific knowledge and also identify new therapeutic targets of inflammatory diseases is imperative. The Center for research in inflammatory diseases (CPDI) will be created with this goal. The general objective of the CPDI will be to perform integrative and translational research to identify, validate and target known and novel biological pathways involved with the induction and resolution of inflammation. As a result, we expect the development of innovative therapeutic strategies and drugs that effectively target inflammatory diseases. The project will involve high-throughput genetic screenings, in vivo and in vitro models of diseases, modeling and chemical synthesis, as well as the discovery of new natural molecules from plants and saliva from arthropods. After selecting the potential drugs and bio-drugs, CPDI will protect the intellectual property and, after partnerships with private companies, coordinate pre-clinical toxicological studies and early clinical trials. The CPDI will also dedicate intense efforts to disseminate knowledge to the general public, in order to fulfill the societal objective of spreading education and generating an enthusiasm for science.. Situação: Em andamento; Natureza: Pesquisa. Integrantes: Helder Takashi Imoto Nakaya - Coordenador / Fernando de Queiroz Cunha - Integrante / Carlos Henrique Tomich de Paula da Silva - Integrante / José Carlos Farias Alves Filho - Integrante / João Santana da Silva - Integrante / Paulo Louzada Junior - Integrante / Rita de Cassia Aleixo Tostes Passaglia - Integrante / Thiago Mattar Cunha - Integrante / Ana Maria Ferreira Roselino - Integrante / Ana Paula de Carvalho Panzeri Carlotti - Integrante / Anibal Basile Filho - Integrante / Antônio Pazin Filho - Integrante / Beatriz Rossetti Ferreira - Integrante / Cacilda da Silva Souza - Integrante / Claudio Miguel da Costa Neto - Integrante / Dario Simoes Zamboni - Integrante / Doralina Guimarães Brum Souza - Integrante / Eduardo Antônio Donadi - Integrante / Eduardo Barbosa Coelho - Integrante / Elcio dos Santos Oliveira Vianna - Integrante / Flavio da Silva Emery - Integrante / Francisco José Albuquerque de Paula - Integrante / Geraldo Aleixo da Silva Passos Júnior - Integrante / Jose Marcos Chaves Ribeiro - Integrante / MARCELLO HENRIQUE NOGUEIRA-BARBOSA - Integrante / Marcos Antonio Rossi - Integrante / Marcos de Carvalho Borges - Integrante / Renê Donizeti Ribeiro de Oliveira - Integrante / Ronaldo de Albuquerque Ribeiro - Integrante / Roque Pacheco de Almeida - Integrante / Sandra Yasuyo Fukada Alves - Integrante / Sergio Henrique Ferreira - Integrante / Vanessa Carregaro Pereira - Integrante / Virginia Paes Leme Ferriani - Integrante / Vânia Luiza Deperon Bonato - Integrante / Waldiceu Aparecido Verri Junior - Integrante / Mateus Simões Flória - Integrante / Juan Dyego Marcelo Azevedo - Integrante / Selma Midori Yamada Shibuya - Integrante. Financiador(es): Fundação de Amparo à Pesquisa do Estado de São Paulo - Auxílio financeiro.
      Membro: Helder Takashi Imoto Nakaya.

Prêmios e títulos

  • Total de prêmios e títulos (6)
    1. Treze Jovens Cientistas selecionados para participar da Academia Intercontinental, University-Based Institutes for Advanced Study.. 2015.
      Membro: Helder Takashi Imoto Nakaya.
    2. Wagner Prize for Matching Vaccines & Genes to Optimize Vaccine Effectiveness, Institute for Operations Research and the Management Sciences (INFORMS).. 2015.
      Membro: Helder Takashi Imoto Nakaya.
    3. Artigo selecionado como "Paper of the year" pela International Society for Vaccines, ISV.. 2011.
      Membro: Helder Takashi Imoto Nakaya.
    4. ACVD-EVC Training Fellowship Award, Australian Centre for Vaccine Development e Emory Vaccine Center.. 2010.
      Membro: Helder Takashi Imoto Nakaya.
    5. Melhor tese do ano de 2007 do programa de pós-graduação em Bioquímica, IQ-USP (São Paulo).. 2007.
      Membro: Helder Takashi Imoto Nakaya.
    6. Prêmio de Melhor Painel do 50o Congresso de Genética, Sociedade Brasileira de Genética.. 2004.
      Membro: Helder Takashi Imoto Nakaya.

Participação em eventos

  • Total de participação em eventos (46)
    1. Júri Virtual Prêmio Péter Murányi 2024. 2024. (Outra).
    2. Antimicrobial Resistance Hackathon.Antimicrobial Resistance Ideas. 2023. (Oficina).
    3. Construção de Repositório e Plataforma de Dados Genômicos no Âmbito do Programa Genomas Brasil. 2023. (Oficina).
    4. Nature Medicine will host a Nature Café on Health Equity: Translating Evidence into Policy and Practice.Integrating databases with DNA. 2023. (Oficina).
    5. Projeto Einstein Cientistas do Amanhã.Inteligência Artificial para Saúde. 2022. (Oficina).
    6. Diploma de Postítulo en Bioinformática y Biología Computacional.Systems Biology. 2021. (Oficina).
    7. Fourth International Symposium on Inflammatory Diseases.Nao se aplica. 2018. (Simpósio).
    8. Forum Área Básica.Pescando ? ?Pescando ?Pescando Boas Ideias Nesse Mar de Dados de Dados Biológicos. 2017. (Simpósio).
    9. Museu do Amanhã - SBI.Inovações na Saúde: O que o Brasil tem a ver com isso?. 2017. (Simpósio).
    10. Nex Biomed USP.Renascença farmacológica: avanços e desafios no desenvolvimento de remédios. 2017. (Encontro).
    11. StartingUP Biotecnologia.StartingUP Biotecnologia. 2017. (Oficina).
    12. 10ª Feira de Profissões. Não se aplica. 2016. (Feira).
    13. 24o Simpósio de Iniciação Científica e Tecnológica da USP.Avaliador. 2016. (Simpósio).
    14. Comunicação científica "Programa Researcher Connect" British Council. 2016. (Oficina).
    15. Congresso da Sociedade Brasileira de Imunologia. 2016. (Congresso).
    16. Encontro de cientistas brasileiros sobre Zika vírus @ Butantan. 2016. (Simpósio).
    17. Keystone Systems Immunology: From Molecular Networks to Human Biology. 2016. (Simpósio).
    18. Nagoya University - Intercontinental Academia.Um dos 13 jovens selecionados. 2016. (Oficina).
    19. Second International Symposium on Inflammatory Diseases-INFLAMMA II.Infection triggering inflammatory diseases. 2016. (Simpósio).
    20. VSV EBOVAC Annual Meeting.Systems Biology of Ebola Vaccine. 2016. (Encontro).
    21. Workshop Medicina Translacional ICB USP.Systems Biology of Inflammatory Processes. 2016. (Oficina).
    22. 26a Semana do ICB da Universidade Federal de Goiás. Palestra. 2015. (Congresso).
    23. Innate Immunity of Infectious and Degenerative Diseases: From Interleukin-1 to Systems Biology.Systems biology of innate immunity. 2015. (Oficina).
    24. Intercontinental Academia.Intercontinental Academia. 2015. (Oficina).
    25. Memorial Event for the 20 Years of the XX Seminário Laveran & Deane so.Assessing the molecular mechanisms of malaria infection through Systems Biology. 2015. (Simpósio).
    26. Munich Workshop ICA.Intercontinental Academia. 2015. (Oficina).
    27. Symmetry and Dynamics in Biology: From experimental analysis to mathematical modeling. Systems vaccinology: learning to compute the behavior of vaccine induced immunity. 2015. (Congresso).
    28. University Global Partnership Network (UGPN).Systems Biology. 2015. (Oficina).
    29. XX Seminário Laveran & Deane sobre Malária.Invited Professor. 2015. (Seminário).
    30. British Society for Immunology Annual Congress. Systems vaccinology: its promise and challenge for vaccine design. 2014. (Congresso).
    31. Human Immunology Project Consortium Nov2014.Systems Biology of influenza vaccination in children, adults and the elderly. 2014. (Simpósio).
    32. Human Immunology Project Consortium semi-annual meeting.Systems analysis of immunity to influenza vaccine in the young and the elderly. 2014. (Simpósio).
    33. ICAAC Interscience Conference on Antimicrobial Agents and Chemotherapy. The Impact of Influenza Vaccines on Functional Genomics in Children and Adults. 2014. (Congresso).
    34. International Conference on Genome Architecture and Cell Fate Regulation. Computation systems biology in immunology: From genes to cells. 2014. (Congresso).
    35. I Simposio en Bioinformática Integrativa. Systems biology of infectious diseases and vaccines. 2014. (Congresso).
    36. XI Encontro de Pós-Graduação da Disciplina de Reumatologia.Biologia de Sistemas de Doenças Infecciosas e Vacinas. 2014. (Simpósio).
    37. XXXIX Congress of The Brazilian Society of Immunology. Systems analysis of immunity to influenza vaccine in the young and the elderly. 2014. (Congresso).
    38. Advanced Immunization Technologies (ADITEC).System Biology Approaches in Vaccinology. 2013. (Simpósio).
    39. CROI 20th Conference on Retroviruses and Opportunistic Infections. Systems Vaccinology: Its Promise and Challenge for HIV Vaccine Development. 2013. (Congresso).
    40. International Alliance for Biological Standardization.Systems Biology to Predict Immunogenicity and Safety of Adjuvants. 2013. (Simpósio).
    41. Keystone Advancing Vaccines in the Genomics Era. Network modeling applied to systems vaccinology: comparative study of 5 human vaccines. 2013. (Congresso).
    42. Osong Symposium on Infectious Diseases. System Vaccinology: It s Promise and Challenge for HIV Vaccine Development. 2013. (Congresso).
    43. International Conference of the American Thoracic Society. Influenza and Systems Biology. 2012. (Congresso).
    44. Human Immunology Project Consortium.MicroRNA signatures of vaccination in humans. 2011. (Simpósio).
    45. XIII Reunião Científica Annual.Systems Vaccinology: Learning to compute the behavior of vaccine induced immunity. 2011. (Simpósio).
    46. NIAID COOPERATIVE CENTERS ON HUMAN IMMUNOLOGY.Systems Biology of Flu Vaccines. 2010. (Simpósio).

Organização de eventos

  • Total de organização de eventos (14)
    1. NAKAYA, HELDER TAKASHI IMOTO. Connecting people to reverse vaccine hypo-responsiveness@Leiden, Holanda. 2024. (Outro).. . 0.
    2. NAKAYA, HELDER TAKASHI IMOTO. II Fórum de Pós-Graduação Einstein. 2022. (Outro).. . 0.
    3. Nakaya, H.. Workshop on Clinical Trials and Immunology. 2020. (Outro).. . 0.
    4. NAKAYA, HELDER TAKASHI IMOTO; FREITAS, L. ; SEVERINO, P.. Human Cell Atlas Latin America. 2020. Congresso
    5. Nakaya, Helder I.; BARGIERI, D.. Evento NAP USP Covid-19: diagnóstico, tratamento e vacinas. 2020. Outro
    6. MINOPRIO, P. ; NAKAYA, H. I. ; ZANOTTO, P. ; FERREIRA, L. C. S. ; BRAGA, P. C. B. B. ; PERON, J. P. S. ; DURIGON, E.. REGIONAL MEETING Regional Director Institut Pasteur International Network (RIIP) Americas. 2019. Outro
    7. Nakaya, Helder Imoto; VIOLA, J. ; OLIVEIRA, C. I. ; BONORINO, C. ; ALVES FILHO, J. C. ; ANTONELLI, L. ; BONAMINO, M.. XLIV Congress of the Brazilian Society of Immunology. 2019. Congresso
    8. NAKAYA, HELDER TAKASHI IMOTO; ALVES-FILHO, J. C. ; CUNHA, T. M. ; CUNHA, F. ; TOSTES, R. ; ZAMBONI, D.. São Paulo School of Advanced Science on Molecular Basis of Inflammatory Diseases. 2019. Congresso
    9. NAKAYA, H. I.; SILVA, T.. Systems Immunology and Bioinformatics workshop (Gâmbia, África). 2018. Outro
    10. Nakaya, Helder I; SOARES, I. ; GAZZINELLI, R. ; BARGIERI, D. ; BOSCARDIN, S. ; SILVEIRA, E.. FAPESP School of Advanced Sciences on Vaccines. 2018. Outro
    11. NAKAYA, H. I.. StartingUP Biotecnologia. 2017. (Outro).. . 0.
    12. MACHADO, R. ; MINOPRIO, P. ; FERREIRA, L. C. ; ZANOTTO, P. ; SILVA JUNIOR, W. ; NAKAYA, H. I.. Beyond Zika. 2016. Outro
    13. GAZZINELLI, R. ; GOLENBOCK, D. ; MENEZES, G. ; Nakaya, Helder I. Innate Immunity of Infectious and Degenerative Diseases: From Interleukin-1 to Systems Biology. 2015. Congresso
    14. NAKAYA, HELDER; RODRIGUES, M.. CBAB: Uso da bioinformática para o estudo de vacinas. 2015. Outro

Lista de colaborações

  • Colaborações endôgenas (9)
    • Helder Takashi Imoto Nakaya ⇔ Sergio Verjovski Almeida (12.0)
      1. FARIAS, LEONARDO PAIVA ; VITORIANO-SOUZA, JULIANA ; CARDOZO, LUCAS ESTEVES ; GAMA, LEONARDO DOS REIS ; SINGH, YOUVIKA ; MIYASATO, PATRÍCIA AOKI ; Almeida, Giulliana Tessarin ; RODRIGUEZ, DUNIA ; BARBOSA, MAYRA MARA FERRARI ; FERNANDES, RAFAELA SACHETTO ; BARBOSA, TEREZA CRISTINA ; NETO, ALMIRO PIRES DA SILVA ; NAKANO, ELIANA ; HO, PAULO LEE ; Verjovski-Almeida, Sergio ; Verjovski-Almeida, S. ; NAKAYA, HELDER IMOTO ; WILSON, ROBERT ALAN ; Leite, Luciana Cezar de Cerqueira. Systems Biology Analysis of the Radiation-Attenuated Schistosome Vaccine Reveals a Role for Growth Factors in Protection and Hemostasis Inhibition in Parasite Survival. Frontiers in Immunology. v. 12, p. 624191, 2021. Qualis: A1
      2. CAIRES-JÚNIOR, LUIZ CARLOS ; GOULART, ERNESTO ; MELO, UIRÁ SOUTO ; ARAUJO, BRUNO HENRIQUE SILVA ; ALVIZI, LUCAS ; SOARES-SCHANOSKI, ALESSANDRA ; DE OLIVEIRA, DANYLLO FELIPE ; KOBAYASHI, GERSON SHIGERU ; GRIESI-OLIVEIRA, KARINA ; MUSSO, CAMILA MANSO ; Amaral, Murilo Sena ; DASILVA, LUCAS FERREIRA ; ASTRAY, RENATO MANCINI ; SUÁREZ-PATIÑO, SANDRA FERNANDA ; VENTINI, DANIELLA CRISTINA ; DA SILVA, SÉRGIO GOMES ; YAMAMOTO, GUILHERME LOPES ; EZQUINA, SUZANA ; NASLAVSKY, MICHEL SATYA ; Verjovski-Almeida, S.. Publisher Correction: Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells. Nature Communications. v. 9, p. 1114, 2018. Qualis: A1
      3. ALMEIDA, GIULLIANA T. ; LAGE, REGINA C. G. ; ANDERSON, LETICIA ; VENANCIO, THIAGO M. ; Nakaya, Helder I. ; MIYASATO, PATRÍCIA A. ; ROFATTO, HENRIQUE K. ; ZERLOTINI, ADHEMAR ; NAKANO, ELIANA ; OLIVEIRA, GUILHERME ; Verjovski-Almeida, Sergio. Synergy of Omeprazole and Praziquantel In Vitro Treatment against Schistosoma mansoni Adult Worms. PLoS Neglected Tropical Diseases (Online). v. 9, p. e0004086, 2015. Qualis: A1
      4. BECKEDORFF, FELIPE C. ; AYUPE, ANA C. ; CROCCI-SOUZA, RENAN ; AMARAL, MURILO S. ; Nakaya, Helder I. ; SOLTYS, DANIELA T. ; MENCK, CARLOS F. M. ; Reis, Eduardo M. ; VERJOVSKI-ALMEIDA, Sergio. The Intronic Long Noncoding RNA ANRASSF1 Recruits PRC2 to the RASSF1A Promoter, Reducing the Expression of RASSF1A and Increasing Cell Proliferation. PLOS Genetics (Online). v. 9, p. e1003705, 2013. Qualis: A1
      5. LOURO, R ; ELJUNDI, T ; NAKAYA, H ; REIS, E ; VERJOVSKIALMEIDA, S ; Verjovski-Almeida, S.. Conserved tissue expression signatures of intronic noncoding RNAs transcribed from human and mouse loci. Genomics (San Diego). v. 92, p. 18-25, 2008. Qualis: A3
      6. LOURO, Rodrigo ; NAKAYA, Helder I. ; AMARAL, Paulo Paiva ; FESTA, Fernanda ; SOGAYAR, Mari Cleide ; SILVA, Aline M. da ; VERJOVSKI-ALMEIDA, Sergio ; REIS, EM. Androgen responsive intronic non-coding RNAs. BMC BIOLOGY, Inglaterra. v. 5:4, n. 4, p. 1-14, 2007. Qualis: Não identificado (BMC BIOLOGY, INGLATERRA)
      7. REIS, EM; Nakaya, Helder I ; Amaral, Paulo P ; LOURO, Rodrigo ; Lopes, André ; FACHEL, Angela A ; Moreira, Yuri B ; El-Jundi, Tarik A ; da Silva, Aline M ; Reis, Eduardo M ; VERJOVSKI-ALMEIDA, Sergio. Genome mapping and expression analyses of human intronic noncoding RNAs reveal tissue-specific patterns and enrichment in genes related to regulation of transcription. GenomeBiology.com (London. Genome Biology. v. 8, p. 1-25, 2007. Qualis: Não identificado (GENOME BIOLOGY)
      8. NAKAYA, Helder I ; BECKEDORFF, Felipe Cesar F ; Baldini, ML ; FACHEL, A. ; REIS, Eduardo M ; Verjovski-Almeida, S. ; Verjovski-Almeida, S.. Splice Variants of TLE Family Genes and Up-Regulation of a TLE3 Isoform in Prostate Tumors.. Biochemical and Biophysical Research Communications,. v. 364, p. 918-923, 2007. Qualis: A3 (BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS)
      9. Reis, Eduardo M. ; LOURO, Rodrigo ; NAKAYA, HELDER I. ; Verjovski-Almeida, Sergio ; Verjovski-Almeida, S.. As Antisense RNA Gets Intronic. Journal of Integrative Biology / Omics (Larchmont), New Rochelle, NY. v. 9, n. 1, p. 2-12, 2005. Qualis: Não identificado (JOURNAL OF INTEGRATIVE BIOLOGY / OMICS , NEW ROCHELLE, NY)
      10. LOURO, Rodrigo ; NAKAYA, HELDER I. ; PAQUOLA, APUÃ C.M. ; MARTINS, ELIZABETH A.L. ; SILVA, ALINE M.DA ; Verjovski-Almeida, Sergio ; Verjovski-Almeida, S. ; Reis, Eduardo M.. RASL11A, member of a novel small monomeric GTPase gene family, is down-regulated in prostate tumors.. Biochemical and Biophysical Research Communications, Estados Unidos. v. 316, n. 3, p. 618-627, 2004. Qualis: A3 (BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS)
      11. REIS, EM; NAKAYA, Helder Ikemoto ; LOURO, Rodrigo ; CANAVEZ, Flavio Canela ; FLATSCHART, Áurea V F ; ALMEIDA, Giulliana Tessarin ; EGIDIO, Camila Moura ; PAQUOLA, Apuã C M ; MACHADO, Abimael A ; FESTA, Fernanda ; YAMAMOTO, Denise ; ALVARENGA, Renato ; DASILVA, Camille C. ; BRITO, Glauber C. ; SIMON, Sérgio D. ; MOREIRA-FILHO, Carlos Alberto ; LEITE, Katia R. ; CAMARA-LOPES, Luiz H. ; CAMPOS, Franz S. ; GIMBA, Etel. Antisense intronic non-coding RNA levels correlate to the degree of tumor differentiation in prostate cancer. Oncogene (Basingstoke), England. v. 23, n. 39, p. 6684-6692, 2004. Qualis: Não identificado (ONCOGENE , ENGLAND)
      12. Nakaya, Helder I.; Reis, Eduardo M. ; VERJOVSKI-ALMEIDA, Sergio. Concepts on microarray design for genome and transcriptome analyses. Em: Anton A. Buzdin; Sergey A. Lukyanov. (Org.). Nucleic Acids Hybridization Modern Applications. 1ed.Berlim. : Springer Netherlands. 2007.p. 265-307.

    • Helder Takashi Imoto Nakaya ⇔ Eduardo Moraes Rego Reis (7.0)
      1. LOURO, R ; ELJUNDI, T ; NAKAYA, H ; REIS, E ; VERJOVSKIALMEIDA, S ; Verjovski-Almeida, S.. Conserved tissue expression signatures of intronic noncoding RNAs transcribed from human and mouse loci. Genomics (San Diego). v. 92, p. 18-25, 2008. Qualis: A3
      2. LOURO, Rodrigo ; NAKAYA, Helder I. ; AMARAL, Paulo Paiva ; FESTA, Fernanda ; SOGAYAR, Mari Cleide ; SILVA, Aline M. da ; VERJOVSKI-ALMEIDA, Sergio ; REIS, EM. Androgen responsive intronic non-coding RNAs. BMC BIOLOGY, Inglaterra. v. 5:4, n. 4, p. 1-14, 2007. Qualis: Não identificado (BMC BIOLOGY, INGLATERRA)
      3. REIS, EM; Nakaya, Helder I ; Amaral, Paulo P ; LOURO, Rodrigo ; Lopes, André ; FACHEL, Angela A ; Moreira, Yuri B ; El-Jundi, Tarik A ; da Silva, Aline M ; Reis, Eduardo M ; VERJOVSKI-ALMEIDA, Sergio. Genome mapping and expression analyses of human intronic noncoding RNAs reveal tissue-specific patterns and enrichment in genes related to regulation of transcription. GenomeBiology.com (London. Genome Biology. v. 8, p. 1-25, 2007. Qualis: Não identificado (GENOME BIOLOGY)
      4. NAKAYA, Helder I ; BECKEDORFF, Felipe Cesar F ; Baldini, ML ; FACHEL, A. ; REIS, Eduardo M ; Verjovski-Almeida, S. ; Verjovski-Almeida, S.. Splice Variants of TLE Family Genes and Up-Regulation of a TLE3 Isoform in Prostate Tumors.. Biochemical and Biophysical Research Communications,. v. 364, p. 918-923, 2007. Qualis: A3 (BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS)
      5. Reis, Eduardo M. ; LOURO, Rodrigo ; NAKAYA, HELDER I. ; Verjovski-Almeida, Sergio ; Verjovski-Almeida, S.. As Antisense RNA Gets Intronic. Journal of Integrative Biology / Omics (Larchmont), New Rochelle, NY. v. 9, n. 1, p. 2-12, 2005. Qualis: Não identificado (JOURNAL OF INTEGRATIVE BIOLOGY / OMICS , NEW ROCHELLE, NY)
      6. REIS, EM; NAKAYA, Helder Ikemoto ; LOURO, Rodrigo ; CANAVEZ, Flavio Canela ; FLATSCHART, Áurea V F ; ALMEIDA, Giulliana Tessarin ; EGIDIO, Camila Moura ; PAQUOLA, Apuã C M ; MACHADO, Abimael A ; FESTA, Fernanda ; YAMAMOTO, Denise ; ALVARENGA, Renato ; DASILVA, Camille C. ; BRITO, Glauber C. ; SIMON, Sérgio D. ; MOREIRA-FILHO, Carlos Alberto ; LEITE, Katia R. ; CAMARA-LOPES, Luiz H. ; CAMPOS, Franz S. ; GIMBA, Etel. Antisense intronic non-coding RNA levels correlate to the degree of tumor differentiation in prostate cancer. Oncogene (Basingstoke), England. v. 23, n. 39, p. 6684-6692, 2004. Qualis: Não identificado (ONCOGENE , ENGLAND)
      7. Nakaya, Helder I.; Reis, Eduardo M. ; VERJOVSKI-ALMEIDA, Sergio. Concepts on microarray design for genome and transcriptome analyses. Em: Anton A. Buzdin; Sergey A. Lukyanov. (Org.). Nucleic Acids Hybridization Modern Applications. 1ed.Berlim. : Springer Netherlands. 2007.p. 265-307.

    • Helder Takashi Imoto Nakaya ⇔ Aline Maria da Silva (5.0)
      1. ZAINI, Paulo A. ; FOGAÇA, A.C. ; LUPO, F.N. G. ; NAKAYA, Helder I ; VENCIO, Ricardo Z N ; DASILVA, A.M.. The Iron Stimulon of Xylella fastidiosa Includes Genes for Type IV Pilus and Colicin V-Like Bacteriocins. Journal of Bacteriology. v. 190, p. 2368-2378, 2008. Qualis: A3
      2. LOURO, Rodrigo ; NAKAYA, Helder I. ; AMARAL, Paulo Paiva ; FESTA, Fernanda ; SOGAYAR, Mari Cleide ; SILVA, Aline M. da ; VERJOVSKI-ALMEIDA, Sergio ; REIS, EM. Androgen responsive intronic non-coding RNAs. BMC BIOLOGY, Inglaterra. v. 5:4, n. 4, p. 1-14, 2007. Qualis: Não identificado (BMC BIOLOGY, INGLATERRA)
      3. REIS, EM; Nakaya, Helder I ; Amaral, Paulo P ; LOURO, Rodrigo ; Lopes, André ; FACHEL, Angela A ; Moreira, Yuri B ; El-Jundi, Tarik A ; da Silva, Aline M ; Reis, Eduardo M ; VERJOVSKI-ALMEIDA, Sergio. Genome mapping and expression analyses of human intronic noncoding RNAs reveal tissue-specific patterns and enrichment in genes related to regulation of transcription. GenomeBiology.com (London. Genome Biology. v. 8, p. 1-25, 2007. Qualis: Não identificado (GENOME BIOLOGY)
      4. LOURO, Rodrigo ; NAKAYA, HELDER I. ; PAQUOLA, APUÃ C.M. ; MARTINS, ELIZABETH A.L. ; SILVA, ALINE M.DA ; Verjovski-Almeida, Sergio ; Verjovski-Almeida, S. ; Reis, Eduardo M.. RASL11A, member of a novel small monomeric GTPase gene family, is down-regulated in prostate tumors.. Biochemical and Biophysical Research Communications, Estados Unidos. v. 316, n. 3, p. 618-627, 2004. Qualis: A3 (BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS)
      5. REIS, EM; NAKAYA, Helder Ikemoto ; LOURO, Rodrigo ; CANAVEZ, Flavio Canela ; FLATSCHART, Áurea V F ; ALMEIDA, Giulliana Tessarin ; EGIDIO, Camila Moura ; PAQUOLA, Apuã C M ; MACHADO, Abimael A ; FESTA, Fernanda ; YAMAMOTO, Denise ; ALVARENGA, Renato ; DASILVA, Camille C. ; BRITO, Glauber C. ; SIMON, Sérgio D. ; MOREIRA-FILHO, Carlos Alberto ; LEITE, Katia R. ; CAMARA-LOPES, Luiz H. ; CAMPOS, Franz S. ; GIMBA, Etel. Antisense intronic non-coding RNA levels correlate to the degree of tumor differentiation in prostate cancer. Oncogene (Basingstoke), England. v. 23, n. 39, p. 6684-6692, 2004. Qualis: Não identificado (ONCOGENE , ENGLAND)

    • Helder Takashi Imoto Nakaya ⇔ André Fujita (2.0)
      1. NAVARRO, BRUNO V ; FERNANDES, PEDRO A ; SANTOS-SILVA, DÉBORA ; FUJITA, ANDRÉ ; KINKER, GABRIELA S ; BUCKERIDGE, MARCOS S ; RIBEIRO-PAZ, EDSON D ; MORAES, CAROLINA BORSOI ; CÓRDOBA-MORENO, MARLINA O ; NAKAYA, HELDER I ; MUXEL, SANDRA M ; JARDIM, VINICIUS C ; MARKUS, REGINA P. Melatonin-Index as a biomarker for predicting the distribution of presymptomatic and asymptomatic SARS-CoV-2 carriers. Melatonin Research. v. 4, p. 189-205, 2021. Qualis: Não identificado (MELATONIN RESEARCH)
      2. WANG, JAQUELINE YU TING ; WHITTLE, MARTIN R. ; PUGA, RENATO DAVID ; YAMBARTSEV, ANATOLY ; FUJITA, ANDRÉ ; Nakaya, Helder I.. Noninvasive prenatal paternity determination using microhaplotypes: a pilot study. BMC Medical Genomics. v. 13, p. 1, 2020. Qualis: A3

    • Helder Takashi Imoto Nakaya ⇔ Carlos Frederico Martins Menck (1.0)
      1. BECKEDORFF, FELIPE C. ; AYUPE, ANA C. ; CROCCI-SOUZA, RENAN ; AMARAL, MURILO S. ; Nakaya, Helder I. ; SOLTYS, DANIELA T. ; MENCK, CARLOS F. M. ; Reis, Eduardo M. ; VERJOVSKI-ALMEIDA, Sergio. The Intronic Long Noncoding RNA ANRASSF1 Recruits PRC2 to the RASSF1A Promoter, Reducing the Expression of RASSF1A and Increasing Cell Proliferation. PLOS Genetics (Online). v. 9, p. e1003705, 2013. Qualis: A1

    • Helder Takashi Imoto Nakaya ⇔ Helena Paula Brentani (1.0)
      1. LÜSCHER DIAS, THOMAZ ; SCHUCH, VIVIANE ; BELTRÃO-BRAGA, PATRÍCIA CRISTINA BALEEIRO ; MARTINS-DE-SOUZA, DANIEL ; Brentani, Helena Paula ; FRANCO, GLÓRIA REGINA ; NAKAYA, HELDER IMOTO. Drug repositioning for psychiatric and neurological disorders through a network medicine approach. Translational Psychiatry. v. 10, p. 141, 2020. Qualis: A1

    • Helder Takashi Imoto Nakaya ⇔ Marcos Silveira Buckeridge (1.0)
      1. NAVARRO, BRUNO V ; FERNANDES, PEDRO A ; SANTOS-SILVA, DÉBORA ; FUJITA, ANDRÉ ; KINKER, GABRIELA S ; BUCKERIDGE, MARCOS S ; RIBEIRO-PAZ, EDSON D ; MORAES, CAROLINA BORSOI ; CÓRDOBA-MORENO, MARLINA O ; NAKAYA, HELDER I ; MUXEL, SANDRA M ; JARDIM, VINICIUS C ; MARKUS, REGINA P. Melatonin-Index as a biomarker for predicting the distribution of presymptomatic and asymptomatic SARS-CoV-2 carriers. Melatonin Research. v. 4, p. 189-205, 2021. Qualis: Não identificado (MELATONIN RESEARCH)

    • Helder Takashi Imoto Nakaya ⇔ Marie-Anne Van Sluys (1.0)
      1. de Mello Varani, Alessandro ; Souza, Rangel Celso ; Nakaya, Helder I. ; de Lima, Wanessa Cristina ; Paula de Almeida, Luiz Gonzaga ; Kitajima, Elliot Watanabe ; Chen, Jianchi ; Civerolo, Edwin ; Vasconcelos, Ana Tereza Ribeiro ; Van Sluys, Marie-Anne. Origins of the Xylella fastidiosa Prophage-Like Regions and Their Impact in Genome Differentiation. Plos One. v. 3, p. e4059, 2008. Qualis: A1

    • Helder Takashi Imoto Nakaya ⇔ Robson Francisco de Souza (1.0)
      1. ARAUJO, JOSÉ DENEY ; SANTOS-E-SILVA, JUAN CARLO ; COSTA-MARTINS, ANDRÉ GUILHERME ; SAMPAIO, VANDERSON ; DE CASTRO, DANIEL BARROS ; de Souza, Robson F. ; GIDDALURU, JEEVAN ; RAMOS, PABLO IVAN P. ; PITA, ROBESPIERRE ; BARRETO, MAURICIO L. ; BARRAL-NETTO, MANOEL ; NAKAYA, HELDER I.. Tucuxi-BLAST: Enabling fast and accurate record linkage of large-scale health-related administrative databases through a DNA-encoded approach. PeerJ. v. 10, p. e13507, 2022. Qualis: A2




(*) Relatório criado com produções desde 2000 até 2024
Data de processamento: 05/12/2024 01:27:53